GD-Ferm™ for microbial and cell fermentation 10 L – 20,000 L
- sterile design, free of dead-leg areas
- integrated CIP / SIP
- high-performance control system with visualisation
- high-quality individual components
- qualified and validatable
- customized solutions
GEA Diessel – impressive performance
GEA Diessel is the specialist in process plant for liquid pharmaceutical products. The name Diessel is well known for progress and expertise in plant and equipment technology all over the world.
Our fermentation systems for the cultivation of microorganisms and human or animal cells have provided manufacturers of pharmaceutical products with maximum performance and economy for over 20 years.
Technical data:
- Unit sizes (working volume in litres):
10, 20, 30, 50, 100, 300, 500,1,000; 1,500 litres
- bigger units according to customer H / D 3:1, 2:1
- Material of product contact surfaces:
SS 316 L/1.4435/1.4404
- Internal surface
Ra ≤ 0,5 µm (≤ 20 µinch) electropolished
- Pressure -1/+3 barSample point
Design
- design in conformity with ASME BPE, reactors in conformity with ASME / PED
- modular structure
- skid-mounted, open frame
- orbital welded pipework
- ports for all media and sensors required in the process
- ports installed flush with the base
- double jacket
- bottom-mounted Rushton turbine agitator with sterile seal flush, optional with magnetic drive
- baffles, removable
- sampling system
Automation
The process is controlled and regulated by a programmable logic control (PLC); all the required values are recorded, e. g.:
- stirring with adjustable speed
- aeration by spargers
- headspace pressure blanketing
- temperature control
- pressure regulation of exhaust air
- filling with nutrient medium
- inoculation
- product harvest
- sterilisation of the nutrient medium by means of temperature control
- empty sterilisation with high purity steam
Qualification
- validation of the software
- compliance with cGMP, GAMP, CFR 21 Part 11
- qualification documentation
Special GEA Diessel services
- comprehensive process expertise in pharmaceutical and biological technology
- project management
- worldwide GEA distribution and service network
- local support on the spot
Visualisation based on the industrial standard for the operation and display of all process functions.