Essential Process Requirements
The processing of blood plasma starts with the gentle thawing of the plasma
with exact temperature maintenance and continues with the individually
developed solids-liquids-separation by means of centrifugation or filtration
for separating the plasma fractions.
To get the Eluat for factor IX extraction, very special filtration
techniques beyond the usual standard are required.
The temperature control - and thus the vessel design and the design of the
stirring elements - is a crucial point for all precipitation steps.
A
design free of deadlegs is vital for a spotless cleanliness and for a
prevention of any loss of valuable product solution. Not only is the safety of
your product important, but also the protection of environment and staff. The
statutory limits for the dosing of the precipitants must be met.
Technologies
For the blood plasma fractionation different techniques are used. The
central part of such plants is always the vessels used for storage, mixing,
precipitation and for reaction, and from which a piping system controls the
product flow. Another loop system feeds all process plants and machines with
the necessary media and utilities. The solids-liquids-separation is carried out
by filtration modules or centrifuges, depending on the application.
Inactivation procedures for viruses are possible either chemically or
thermally, depending on the situation. Ultra-, Dia- and Nanofiltration assist
in the separation of the product from the liquid phase, in change of buffer
solution or in the concentration of the product solution.
Automated system
GEA Diessel provides for all important parameters to be monitored
by a high-performance control system, with all processes being visualised. The
control system automatically administers all parameters and records and
documents all data, steps and parameters that are important to the process.
For detailed information please refer to our brochure "Complete Solutions for Process Plant /
Blood Plasma".